Best 38 Profitable Business Ideas for Nurses in 2025

The healthcare sector is booming, and nurses are well-placed to capitalize on its expanding business prospects. If you possess nursing expertise and entrepreneurial skills, opening your own business might be your next step. In this article, our industry experts have discussed the top nursing business ideas, ranging from lucrative side hustles, home businesses, and full-time ventures that enable you to monetize your passion for care into a successful career.

Why Start a Nursing Business?

The healthcare industry is changing at a rapid pace, opening up new and interesting opportunities for nurses beyond the conventional hospital setting. With their exceptional skill set, empathy, and medical knowledge, numerous nurses are now entering into entrepreneurship, providing services that address growing health needs. Whether you are an RN, NP, LPN, or retired nurse, becoming a nursing business owner can be the next exciting step.

In the United States, there are about 3 million active registered nurses. The median annual income of a Licensed Registered Nurse (L.N.P) in the U.S. is approximately $75,510 annually on average. Some of the main reasons of starting a nursing business are as follows:

• Higher Earnings: Nurse entrepreneurs often outearn staff positions (e.g., IV therapy nurses make $100−$300 per session).
• Flexibility: Set your own hours and work remotely (telehealth, consulting).
• Growing Demand: Aging population, corporate wellness trends, and telehealth expansion create opportunities.
• Rewarding: Make a Difference While Earning Well

Best 38 Nursing Businesses to Start

1. Private Duty Nursing Services

Private duty nursing is among the most profitable nursing business ideas for RNs and LPNs. Private duty nurses offer one-to-one, customized care to homebound or institutional patients. It is a sought-after service by elderly, post-operative, or chronically ill patients needing special attention.

• Startup Cost: Moderate
• Potential Earnings: $60,000–$100,000+ per year.

2. Senior Care / Non-Medical Home Care Agency

Opening a non-medical senior care agency is one of the most secure nursing business ventures today. You will help seniors with activities of daily living such as bathing, meal preparation, transportation, and companionship. With America’s elderly population on the rise, non-medical home care services are becoming vital.

• Moderate to High (depending on licensing)
• Potential Earnings: $50,000–$120,000+ annually.

3. Concierge Nursing Services

Concierge nurses offer on-demand, private nursing care to patients who want top-notch, highly individualized health care. Post-surgical patients, affluent individuals, or those who need wellness assistance at home could be among the customers. This kind of business model typically commands higher rates due to exclusivity and convenience offered.

• Startup Cost: Low to Moderate
• Potential Earnings: $75,000–$200,000+ per year.

4. Telehealth Nurse Consultant

With the rise of virtual healthcare, becoming a telehealth nurse consultant is one of the smartest business ideas for registered nurses today. Nurses, as telehealth consultants, can remotely provide education, follow-up care, and chronic illness support to patients. It’s a flexible business model with low overhead and a rapidly growing market.

• Startup Cost: Very Low
• Potential Earnings: $50,000–$90,000 per year.

5. Nurse Health Coaching

Health coaching is a booming field, making it an exciting nursing entrepreneur idea. Nurse health coaches guide clients in lifestyle changes, chronic disease prevention, nutrition, and wellness. You can offer coaching online, in clinics, or through corporate wellness programs.

• Startup Cost: Low
• Potential Earnings: $40,000–$100,000+ annually.

6. Legal Nurse Consultant

Legal nurse consulting offers a unique twist for nurses who want to work with law firms. As a legal nurse consultant, you’ll review medical records, interpret medical issues, and offer expert advice in legal cases. It’s a lucrative nursing business opportunity if you enjoy both healthcare and law.

• Startup Cost: Low (after certification)
• Potential Earnings: $60,000–$150,000+ per year.

7. Corporate Wellness Programs

Corporate wellness nurses design health initiatives for businesses, including health screenings, fitness challenges, nutrition counseling, and stress management workshops. Companies invest heavily in employee health to boost productivity and reduce healthcare costs. This nursing entrepreneur idea offers flexibility and long-term client relationships.

• Startup Costs: $3,000–$8,000 (certifications, marketing, program materials)
• Potential Earnings: $75,000–$150,000+ per year

8. Nurse Staffing Agency

A nurse staffing agency connects healthcare professionals with hospitals, clinics, and long-term care facilities facing staff shortages. With the ongoing healthcare workforce challenges, this is one of the highest-earning nursing entrepreneur ideas. Though it requires some investment upfront, the potential rewards are huge.

• Startup Cost: High
• Potential Earnings: $150,000–$500,000+ annually.

9. IV Hydration Therapy Business

IV hydration therapy is a fast-growing sector that nurses can tap into with the right certifications. Services often include vitamin infusions, hydration treatments for athletes, and hangover recovery therapies. This is one of the trendiest nursing business ideas for nurses looking to combine wellness and healthcare.

• Startup Cost: Moderate to High (depending on setup)
• Potential Earnings: $100,000+ per year.

10. Mobile Phlebotomy Services

Starting a mobile phlebotomy business is a low-cost, in-demand opportunity for nurses and phlebotomy-certified professionals. You will visit patients at home, in workplaces, or in senior living facilities to collect blood samples. This business meets the increasing demand for convenient healthcare services.

• Startup Cost: Low to Moderate
• Potential Earnings: $45,000–$85,000 annually.

11. Nurse Educator or NCLEX Tutor

Helping the next generation of nurses succeed is another inspiring nursing business idea. As a nurse educator or NCLEX tutor, you can provide exam preparation services, teach CPR courses, or conduct online nursing classes. Education-focused businesses often have flexible schedules and low startup costs.

• Startup Cost: Very Low
• Potential Earnings: $30,000–$70,000 per year.

12. Medical Aesthetics Nurse

An esthetician is a licensed skin specialist. Broadly, the services include clean skin through skin exfoliation, Botox, dermal fillers, massage, aromatherapy, and facials. You can find available courses through the American Association of Aesthetic Medicine and Surgery and other similar organizations. The demand for this type of service is increasing very fast.

• Startup Cost: Moderate (plus training)
• Potential Earnings: $80,000–$200,000+ annually.

Read: How to Start a Medical Aesthetic Clinic Business

13. Occupational Health Consultant

Becoming an occupational health consultant allows nurses to work with companies to improve employee health and workplace safety. Services might include conducting screenings, creating wellness programs, and managing workers’ compensation cases. It’s a fantastic option for nurses passionate about public health and corporate wellness.

• Startup Cost: Low to Moderate
• Potential Earnings: $60,000–$120,000 per year.

14. Vaccination & Wellness Clinics

Nurses can open small clinics focused on vaccinations, preventive care, and wellness screenings for flu, COVID-19, travel vaccines, and more. These clinics can operate independently or partner with schools, companies, or community centers. The growing emphasis on preventive healthcare makes this a strong nurse-owned business.

• Startup Costs: $10,000–$30,000 (clinic space, vaccines, licensing)
• Potential Earnings: $80,000–$200,000+ annually

15. Lactation Consulting

Certified lactation consultants help new mothers with breastfeeding education, techniques, and troubleshooting. Nurses with a background in maternal-child health can provide home visits, virtual consultations, or hospital partnerships. Demand for lactation support is strong, especially with the rise of breastfeeding advocacy in healthcare.

• Startup Costs: $2,000–$5,000 (certifications, equipment, marketing)
• Potential Earnings: $50,000–$90,000 annually

16. Medical Writing

Nurses with strong writing skills can create content for healthcare websites, journals, pharmaceutical companies, and educational organizations. Topics range from patient education to clinical research articles and product marketing. Medical writing is a highly flexible nursing business idea that allows remote work and good income.

• Startup Costs: $1,000–$3,000 (training courses, website setup, marketing)
• Potential Earnings: $60,000–$120,000+ annually

17. Nurse-Invented Products

Nurses often identify gaps in healthcare tools and products, leading them to invent solutions such as patient care devices, comfort items, or innovative scrubs. You can license your invention, manufacture it yourself, or partner with companies. This nursing entrepreneur opportunity can be highly profitable if your product solves a real problem.

• Startup Costs: $5,000–$50,000 (prototyping, patents, manufacturing)
• Potential Earnings: Varies widely ($50,000 to multi-million dollars)

18. Senior Safety Kits

Senior safety kits provide essential products like fall prevention tools, medication organizers, mobility aids, and emergency alert systems. Nurses can design and sell customized kits online or through partnerships with senior living facilities. It’s a creative small business idea for nurses that focuses on improving elderly safety at home.

• Startup Costs: $2,000–$7,000 (product sourcing, branding, website)
• Potential Earnings: $40,000–$100,000+ per year

19. Medical Spa Nurse

Medical spa nurses offer non-invasive cosmetic treatments like Botox, fillers, microneedling, chemical peels, and skincare consultations under physician oversight. This is one of the most lucrative nursing business ideas in the wellness and beauty sector. Proper training and certifications are required, but the market demand is strong.

• Startup Costs: $15,000–$50,000 (training, equipment, clinic setup)
• Potential Earnings: $100,000–$250,000+ annually

20. Cannabis Nursing

Cannabis nurses educate patients about using medical cannabis safely for conditions like chronic pain, anxiety, and cancer-related symptoms. With legalization expanding, this niche field offers counseling, treatment planning, and advocacy services. This emerging nursing business opportunity blends healthcare expertise with holistic patient care.

• Startup Costs: $2,000–$6,000 (training, certifications, marketing)
• Potential Earnings: $50,000–$100,000+ annually

Read: Top Healthcare Business Ideas

Specialized Nursing Business Ideas

21. Massage Therapy

Nurses trained in massage therapy can offer therapeutic and medical massages for pain relief, injury recovery, and relaxation. Combining nursing knowledge with bodywork techniques makes you stand out in the competitive massage industry. It’s a popular nursing entrepreneur idea for those passionate about holistic care.

• Startup Costs: $5,000–$10,000 (massage therapy certification, table, supplies)
• Potential Earnings: $50,000–$100,000+ per year

22. Nursing Career Advisor

As a Nursing Career Advisor, you can guide aspiring nurses on education paths, licensing, certifications, and career opportunities. You can offer one-on-one counseling, resume building, interview preparation, and career workshops. This is a low-cost nursing business idea ideal for experienced nurses passionate about mentoring.

• Startup Costs: $1,000–$3,000 (website, marketing, certifications if needed)
• Potential Earnings: $50,000–$90,000+ annually

23. Child Care Center or Creche

Nurses can open child care centers or creches that provide a higher level of health and safety for children, which parents highly value. You can specialize in infant care, after-school care, or care for children with special medical needs. This is a strong business opportunity for nurses who love working with kids.

• Startup Costs: $15,000–$50,000 (facility setup, licensing, staff)
• Potential Earnings: $75,000–$200,000+ per year

24. Diagnostic Center

Nurses can partner with physicians or laboratories to set up diagnostic centers offering blood tests, X-rays, ultrasounds, and preventive screenings. You’ll need compliance with health regulations, but the demand for accessible diagnostics is growing. This is one of the more capital-intensive but profitable nursing business ideas.

• Startup Costs: $50,000–$200,000+ (equipment, licensing, staff)
• Potential Earnings: $150,000–$500,000+ annually

25. Herbal Medecine Selling

Nurses with knowledge of holistic health can sell herbal remedies, essential oils, and natural supplements through online stores or physical outlets. There’s a rising demand for alternative medicine and natural wellness products in the United States. This can be a profitable nursing business idea with low overhead.

• Startup Costs: $2,000–$8,000 (inventory, website, certifications if required)
• Potential Earnings: $40,000–$120,000+ annually

26. Life Care Planner

Life Care Planners create detailed care plans for individuals dealing with catastrophic injuries, chronic illnesses, or disabilities, often working with legal and insurance professionals. As a certified Life Care Planner, a nurse can help secure necessary funding for long-term patient needs. This highly specialized nursing career business idea is very lucrative.

• Startup Costs: $3,000–$8,000 (certifications, marketing, professional memberships
• Potential Earnings: $80,000–$200,000+ annually

27. Maternity Clinic

Experienced maternity nurses can open private maternity clinics offering prenatal care, birthing classes, and postpartum support (in states where regulations allow). Many families seek personalized maternity services outside traditional hospitals. This is a meaningful and profitable nursing business idea.

• Startup Costs: $50,000–$150,000+ (facility, equipment, licensing)
• Potential Earnings: $100,000–$300,000+ annually

28. Nephrology Nurse

Nurses specializing in nephrology can offer at-home dialysis services, kidney care consulting, and patient education. Chronic kidney disease is a growing health concern in the U.S., and these services are in high demand. This niche nursing business idea requires specialized certifications but offers stable income.

• Startup Costs: $5,000–$15,000 (certifications, equipment, marketing)
• Potential Earnings: $80,000–$150,000+ annually

29. Nutrition Consultant

Nutrition Consultants help clients manage weight, diabetes, heart disease, and general wellness through diet planning. Nurses with a background in nutrition can offer both one-on-one sessions and group programs. This is a flexible and fast-growing small business idea for nurses interested in preventive health.

• Startup Costs: $2,000–$5,000 (certifications, website, marketing)
• Potential Earnings: $50,000–$100,000+ per year

30. Chronic Disease Management Services

Chronic Disease Management Services help patients manage ongoing conditions like diabetes, hypertension, asthma, and arthritis through monitoring, education, and coordination with physicians. Nurses can offer in-person or telehealth services to reduce hospitalizations and improve quality of life. It’s a booming nursing business opportunity with consistent client needs.

• Startup Costs: $3,000–$10,000 (certifications, EMR software, marketing)
• Potential Earnings: $75,000–$150,000+ annually

31. Health Blogger

Nurses can start a health blog sharing trusted information on wellness, disease prevention, healthcare careers, and patient education. By building an audience, you can earn money through ads, sponsored posts, affiliate marketing, and digital products. A health blog is a low-cost nursing business idea that offers passive income potential over time.

• Startup Costs: $500–$2,000 (domain, hosting, website design, marketing)
• Potential Earnings: $1,000–$10,000+ monthly (depending on traffic)

Read: How to Start a Blog and Make Money

32. Nursing YouTube Channel

Creating a YouTube channel focused on nursing education, career advice, health tips, or daily nursing life can build a loyal following. Video content is highly consumed, and nurses can monetize through ads, sponsorships, memberships, and courses. This is a modern, creative nursing entrepreneur idea with a global reach.

• Startup Costs: $500–$2,500 (camera, microphone, editing software, branding)
• Potential Earnings: $1,000–$20,000+ monthly (based on views and sponsorships)

33. Nurse Health Tutor

Nurses can offer private tutoring for nursing students preparing for NCLEX exams, nursing school entry, certifications, and continuing education. One-on-one or group coaching, either online or offline, is in high demand. It’s a rewarding nursing business opportunity for those who enjoy teaching and mentoring.

• Startup Costs: $1,000–$3,000 (website, marketing, course materials
• Potential Earnings: $50,000–$100,000+ annually

34. Nurse Influencer

Nurse influencers build audiences on platforms like Instagram, TikTok, or LinkedIn by sharing healthcare knowledge, humor, real-life nursing experiences, and brand collaborations. They work with brands for promotions, speak at events, or create their own product lines. This trendy nursing business idea offers creativity and income diversity.

• Startup Costs: $500–$3,000 (branding, content creation tools, social media ads)
• Potential Earnings: $1,000–$20,000+ monthly (depending on followers)

35. Childbirth Educator or Doula Services

Nurses can become certified childbirth educators or doulas to provide education, emotional support, and non-medical assistance before, during, and after childbirth. With growing interest in natural birthing and holistic support, this service is highly valued. It’s a fulfilling and flexible business idea for nurses passionate about maternal health.

• Startup Costs: $2,000–$5,000 (certifications, marketing, supplies)
• Potential Earnings: $50,000–$100,000+ annually

36. Herbal Medicine Selling

Nurses can curate and sell herbal supplements, teas, tinctures, and wellness kits through e-commerce stores or local shops. With careful research and partnerships with certified suppliers, nurses can build a trusted brand. This natural health-focused nursing business opportunity taps into growing consumer demand for alternative medicine.

• Startup Costs: $2,000–$8,000 (inventory, website, compliance)
• Potential Earnings: $40,000–$120,000+ annually

37. Yoga Instructor

Nurses trained as certified yoga instructors can offer classes focusing on stress reduction, chronic disease management, or prenatal/postnatal care. Yoga aligns perfectly with healthcare, offering a preventive wellness model. This nursing side business idea blends physical health, mental wellness, and community building.

• Startup Costs: $2,000–$5,000 (yoga teacher certification, mats, studio rental)
• Potential Earnings: $30,000–$80,000+ annually

38. Life Care Planner

Life Care Planners specialize in creating detailed, long-term medical care and cost plans for patients with serious injuries or chronic illnesses, often supporting legal cases. Nurses with certification in life care planning can work independently, with law firms, or insurance companies. This is a highly respected and high-earning nursing business model.

• Startup Costs: $3,000–$8,000 (certifications, business setup, marketing)
• Potential Earnings: $80,000–$200,000+ annually

Frequently Asked Questions

 What is the most profitable nursing business idea?

Home healthcare services, nurse staffing agencies, and concierge nursing tend to be the most profitable because of the high demand and relatively high service fees.

Can a nurse start a business without leaving their job?

Yes! Many nurses start side businesses like tutoring, blogging, or consulting while working part-time or full-time, gradually transitioning into entrepreneurship.

How much does it cost to start a nursing business?

Startup costs can range from as low as $500 (for blogging or online consulting) to $50,000+ (for healthcare staffing agencies or diagnostic centers).

Do I need a license to start a nursing business?

Depending on the business type and state laws, you might need special licenses, permits, insurance, or certifications to operate legally.

What are the key challenges in the nursing staffing agency business?

Major challenges in nursing staffing agencies may include recruitment difficulties, fluctuating demand, managing scheduling conflicts, and ensuring regulatory compliance in the healthcare staffing industry.

Conclusion

The world of medicine is rapidly evolving, creating new and fascinating ventures for nurses outside the typical hospital environment. You can offer services that meet emerging needs for healthcare with a superior skill set, compassion, and medical expertise. Whether you are an RN, NP, LPN, or are a retired nurse, becoming a business owner as a nurse can be the next adventure.